Gregory A. Weiss
Chemistry, School of Physical Sciences
Molecular Biology & Biochemistry, School of Biological Sciences
Phone: (949) 824-5566
Email: gweiss@uci.edu
http://chem.ps.uci.edu/~gweiss/
http://www.faculty.uci.edu/profile.cfm?faculty_id=4565
Gregory Weiss
The Weiss laboratory applies diverse techniques to approach the challenges of characterization and diagnosis of tumorigenesis. In collaboration with Profs. Reg Penner and Phil Collins, they have developed systems for direct interface of biological recognition with electronics. For example, they have recently reported “virus electrodes,” which feature filamentous bacteriophage tether directly to electrodes. They can tailor the phage to bind to the prostate specific membrane antigen for direct, reagentless, rapid, real-time detection of this cancer marker. This bioelectronics interface can be pushed down to the single molecule level, where Dr. Weiss plans to study differences in dynamics between wild-type and cancer-associated proteins. They also apply phage-displayed protein libraries to identify soluble, yet functional, variants of cancer-associated proteins. For example, recently they identified a soluble variant of caveolin, and used phage-displayed shotgun scanning to map the sidechain requirements for caveolin function associated with cancer. Structural studies of caveolin and other proteins are underway in the laboratory.
Selected Publications:
Yang, L. M., Tam, P. Y., Murray, B. J., McIntire, T. M., Overstreet, C. M., Weiss, G. A., and Penner, R. M. (2006). Virus electrodes for universal biodetection. Anal Chem 78(10), 3265-70.
Goldsmith, B. R., Coroneus, J. G., Khalap, V. R., Kane, A. A., Weiss, G. A., and Collins, P. G. (2007). Conductance-controlled point functionalization of single-walled carbon nanotubes. Science 315(5808), 77-81.
Levin, A. M., Murase, K., Jackson, P. J., Flinspach, M. L., Poulos, T. L., and Weiss, G. A. (2007). Double barrel shotgun scanning of the caveolin-1 scaffolding domain. ACS Chem Biol 2(7), 493-500.
Yang, L. M., Diaz, J. E., McIntire, T. M., Weiss, G. A., and Penner, R. M. (2008). Covalent virus layer for mass-based biosensing. Anal Chem 80(4), 933-43. |
