William Edward Robinson
Pathology, School of Medicine
Microbiology & Molecular Genetics, School of Medicine
Medicine, School of Medicine
Phone: (949) 824-3431
Email: ewrobins@uci.edu
www.ucihs.uci.edu/com/pathology/faculty/erobinson.html
http://www.faculty.uci.edu/profile.cfm?faculty_id=3219
W. Edward Robinson III
Dr. Robinson’s laboratory is interested in two cancer related projects. The first is the development of inhibitors of human immunodeficiency virus (HIV) integrase. Integrase is an enzyme that plays a critical role in the HIV life cycle. By inhibiting integration, HIV cannot replicate. Thus, inhibitors of integrase would slow progression of the disease towards acquired immune deficiency syndrome (AIDS). Since AIDS is a cofactor in a number of neoplasias, including lymphomas, Kaposi’s sarcoma, and cervical carcinoma, the inhibition of integration would decrease the incidence of these disorders. The second area of research interest with a cancer focus is their studies on the mechanisms of integration. It is well documented that integration can lead directly to oncogenic transformation. By better understanding integration, they will have a better idea of the mechanisms by which retroviruses cause neoplasia.
Selected Publications:
Reinke, R. A., Lee, D. J., McDougall, B. R., King, P. J., Victoria, J., Mao, Y., Lei, X., Reinecke, M. G., and Robinson, W. E., Jr. (2004). L-chicoric acid inhibits human immunodeficiency virus type 1 integration in vivo and is a noncompetitive but reversible inhibitor of HIV-1 integrase in vitro. Virology 326(2), 203-19.
Robinson, W. E. (2006). Mechanism for complement-mediated, antibody-dependent enhancement of human immunodeficiency virus type 1 infection in MT2 cells is enhanced entry through CD4, CD21, and CXCR4 chemokine receptors. Viral Immunol 19(3), 434-47.
Charvat, T. T., Lee, D. J., Robinson, W. E., and Chamberlin, A. R. (2006). Design, synthesis, and biological evaluation of chicoric acid analogs as inhibitors of HIV-1 integrase. Bioorg Med Chem 14(13), 4552-67.
Lee, D. J., and Robinson, W. E., Jr. (2006). Preliminary mapping of a putative inhibitor-binding pocket for human immunodeficiency virus type 1 integrase inhibitors. Antimicrob Agents Chemother 50(1), 134-42.
Peterson, M. A., Ke, P., Shi, H., Jones, C., McDougall, B. R., and Robinson, W. E., Jr. (2007). Design, synthesis, and antiviral evaluation of some 3'-carboxymethyl-3'-deoxyadenosine derivatives. Nucleosides Nucleotides Nucleic Acids 26(5), 499-519. |
