John Leslie Redpath
Radiation Oncology, School of Medicine
Phone: (949) 824-7395
Email: jlredpat@uci.edu
http://www.faculty.uci.edu/profile.cfm?faculty_id=2879
J. Leslie Redpath
The major focus of current research in Dr. Redpath's laboratory is on quantitative and mechanistic aspects of the adaptive response against spontaneous neoplastic transformation that is induced by low doses of ionizing radiation. These studies have important implications for the assessment of risk associated with exposure to low doses of low LET radiation. A recent finding is that an adaptive response against neoplastic transformation can be mounted in cells exposed to very low dose-rate radiation (300x above background). In addition, Dr. Redpath has had an interest in the consequences of loss of function of p53 on radiation-induced cell cycle checkpoint function and the implications for the fate of the irradiated cell. This project is being done in collaboration with Dr. Stanbridge (UCI). A recent novel finding is the requirement for p53-dependent Chk1 phosphorylation for the maintenance of prolonged G2 arrest. Dr. Redpath also collaborates with Dr. Elmore (UCI) on the development and application of human cell-based assays to screen for the efficacy of candidate chemopreventive agents. This includes the identification of biomarkers that may be of value to monitor response chemopreventive treatment in the clinical setting. A recent finding is that the ratio of N-to E-cadherin protein expression levels may be a useful indicator of chemopreventive effect in human melanoma.
Selected Publications:
Pant, M. C., Liao, X. Y., Lu, Q., Molloi, S., Elmore, E., and Redpath, J. L. (2003). Mechanisms of suppression of neoplastic transformation in vitro by low doses of low LET radiation. Carcinogenesis 24(12), 1961-5.
Elmore, E., Lao, X. Y., Kapadia, R., and Redpath, J. L. (2006). The effect of dose rate on radiation-induced neoplastic transformation in vitro by low doses of low-LET radiation. Radiat Res 166(6), 832-8.
Ko, M., Lao, X. Y., Kapadia, R., Elmore, E., and Redpath, J. L. (2006). Neoplastic transformation in vitro by low doses of ionizing radiation: role of adaptive response and bystander effects. Mutat Res 597(1-2), 11-7.
Elmore, E., Jain, A., Siddiqui, S., Tohidian, N., Meyskens, F. L., Steele, V. E., and Redpath, J. L. (2007). Development and characteristics of a human cell assay for screening agents for melanoma prevention. Melanoma Res 17(1), 42-50.
Wang, X. Q., Stanbridge, E. J., Lao, X., Cai, Q., Fan, S. T., and Redpath, J. L. (2007). p53-dependent Chk1 phosphorylation is required for maintenance of prolonged G2 Arrest. Radiat Res 168(6), 706-15. |
