Steven M. Lipkin
Medicine, School of Medicine
Biological Chemistry, School of Medicine
Epidemiology, School of Medicine
Phone: (949) 824-9219
Email: slipkin@uci.edu
www.ucihs.uci.edu/biochem/faculty/LIPKIN.html
Dept. of Epidemiology - School of Medicine
http://www.faculty.uci.edu/profile.cfm?faculty_id=4707
Steven Lipkin
Dr. Lipkin’s long-term objectives are to perform basic and translational research on GI cancers. His goal is to discover and validate markers with greater information content than family medical history alone to define high risk groups for intensive cancer surveillance, prophylactic surgery and/or chemoprevention.
Towards this end, Dr. Lipkins uses approaches of Molecular Epidemiology (discovery of novel susceptibility alleles that underlie inherited cancer susceptibility and influence pharmacogenetic response), Mouse Models (validation of genes as germline candidates for human disease), Molecular Chemoprevention (Phase IIa trial of Tarceva in IPMNs, a precursor of pancreatic adenocarcinoma), and mechanistic studies to understand the fundamental biological foundation of the above lines of investigation.
Selected Publications:
Cannavo, E., Marra, G., Sabates-Bellver, J., Menigatti, M., Lipkin, S. M., Fischer, F., Cejka, P., and Jiricny, J. (2005). Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair. Cancer Res 65(23), 10759-66.
Frank, S. A., Chen, P. C., and Lipkin, S. M. (2005). Kinetics of cancer: a method to test hypotheses of genetic causation. BMC Cancer 5, 163.
Chao, E. C., and Lipkin, S. M. (2006). Molecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesis. Nucleic Acids Res 34(3), 840-52.
Wu, X., Tsai, C. Y., Patam, M. B., Zan, H., Chen, J. P., Lipkin, S. M., and Casali, P. (2006). A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation. J Immunol 176(9), 5426-37.
Lipkin, S. M., and Afrasiabi, K. (2007). Familial colorectal cancer syndrome X. Semin Oncol 34(5), 425-7.
Zell, J. A., Rhee, J. M., Ziogas, A., Lipkin, S. M., and Anton-Culver, H. (2007). Race, socioeconomic status, treatment, and survival time among pancreatic cancer cases in California. Cancer Epidemiol Biomarkers Prev 16(3), 546-52.
Velasquez, J. L., and Lipkin, S. M. (2007). Genetic testing to identify high-risk populations for chemoprevention studies. Cancer Biomark 3(3), 163-8.
Pan, Z., Sikandar, S., Witherspoon, M., Dizon, D., Nguyen, T., Benirschke, K., Wiley, C., Vrana, P., and Lipkin, S. M. (2008). Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice. Dev Dyn 237(2), 316-27.
Chao, E. C., Velasquez, J. L., Witherspoon, M. S., Rozek, L. S., Peel, D., Ng, P., Gruber, S. B., Watson, P., Rennert, G., Anton-Culver, H., Lynch, H., and Lipkin, S. M. (2008). Accurate classification of MLH1/MSH2 missense variants with multivariate analysis of protein polymorphisms-mismatch repair (MAPP-MMR). Hum Mutat. |
