Arthur D. Lander
Developmental & Cell Biology, School of Biological Sciences
Phone: (949)824-1721
Email: adlander@uci.edu
lander-office.bio.uci.edu/landerfacts.html
http://www.faculty.uci.edu/profile.cfm?faculty_id=2682
Arthur Lander
The Lander lab focuses on how cells communicate to coordinate behaviors that underlie development, regeneration and cancer. Many of the projects in the lab take a systems biology approach to explaining biological complexity.
One project uses experimental and computational approaches to understand co-receptors—molecules that boost performance of cell surface receptors—and their roles in growth, morphogen signaling and cancer. One of these co-receptors, Glypican-1, is specifically up-regulated in pancreatic and breast cancer, and the Lander lab, in collaboration with the lab of Murray Korc at Dartmouth, has demonstrated a key role for Glypican-1 in pancreatic tumor growth and metastasis.
Another project in the lab models effects of feedback loops in multi-stage lineages in the control of proliferation and growth. This work demonstrates how highly unstable, oscillatory proliferative dynamics—such as are commonly seem in hematological malignancies—easily arise from feedback loops that are normally used to help control regeneration.
Selected Publications:
Karumanchi, S. A., Jha, V., Ramchandran, R., Karihaloo, A., Tsiokas, L., Chan, B., Dhanabal, M., Hanai, J. I., Venkataraman, G., Shriver, Z., Keiser, N., Kalluri, R., Zeng, H., Mukhopadhyay, D., Chen, R. L., Lander, A. D., Hagihara, K., Yamaguchi, Y., Sasisekharan, R., Cantley, L., and Sukhatme, V. P. (2001). Cell surface glypicans are low-affinity endostatin receptors. Mol Cell 7(4), 811-22.
Matsuda, K., Maruyama, H., Guo, F., Kleeff, J., Itakura, J., Matsumoto, Y., Lander, A. D., and Korc, M. (2001). Glypican-1 is overexpressed in human breast cancer and modulates the mitogenic effects of multiple heparin-binding growth factors in breast cancer cells. Cancer Res 61(14), 5562-9.
Ding, K., Lopez-Burks, M., Sanchez-Duran, J. A., Korc, M., and Lander, A. D. (2005). Growth factor-induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cells. J Cell Biol 171(4), 729-38.
Kim, J., Wu, H. H., Lander, A. D., Lyons, K. M., Matzuk, M. M., and Calof, A. L. (2005). GDF11 controls the timing of progenitor cell competence in developing retina. Science 308(5730), 1927-30.
Aikawa, T., Whipple, C. A., Lopez, M. E., Gunn, J., Young, A., Lander, A. D., and Korc, M. (2008). Glypican-1 modulates the angiogenic and metastatic potential of human and mouse cancer cells. J Clin Invest 118(1), 89-99. |
