Peter Kaiser
Biological Chemistry, School of Medicine
Phone: (949) 824-9442
Email: pkaiser@uci.edu
http://webfiles.uci.edu/pkaiser/www/pk-webpage.html
http://www.faculty.uci.edu/profile.cfm?faculty_id=4706
Peter Kaiser
Research in Dr. Kaiser’s laboratory is focused on aspects of regulation of cell proliferation, with particular consideration of the role of ubiquitination in cell cycle progression. They are interested in how metabolites (S-adenosylmethionine, methionine, and homocysteine) connect to cell cycle control and how these signaling pathways can be exploited in cancer therapy. In addition, they study the role of heavy metals in regulating cell proliferation.
A second research direction in the laboratory involves a proteome-wide approach to profile ubiquitinated proteins and sumoylated proteins to identify misregulated modifications related to cancer.
As a third research direction they are using high-throughput small molecule screens to identify compounds that can reactivate mutant versions of the tumor suppressor protein p53 that are found in cancer cells. Restoring p53 function in tumors has been demonstrated to reverse tumor growth in animal models and is therefore an attractive strategy for cancer treatment.
Selected Publications:
Flick, K., Ouni, I., Wohlschlegel, J. A., Capati, C., McDonald, W. H., Yates, J. R., and Kaiser, P. (2004). Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain. Nat Cell Biol 6(7), 634-41.
Yen, J. L., Su, N. Y., and Kaiser, P. (2005). The yeast ubiquitin ligase SCFMet30 regulates heavy metal response. Mol Biol Cell 16(4), 1872-82.
Su, N. Y., Flick, K., and Kaiser, P. (2005). The F-box protein Met30 is required for multiple steps in the budding yeast cell cycle. Mol Cell Biol 25(10), 3875-85.
Flick, K., Raasi, S., Zhang, H., Yen, J. L., and Kaiser, P. (2006). A ubiquitin-interacting motif protects polyubiquitinated Met4 from degradation by the 26S proteasome. Nat Cell Biol 8(5), 509-15.
Tagwerker, C., Flick, K., Cui, M., Guerrero, C., Dou, Y., Auer, B., Baldi, P., Huang, L., and Kaiser, P. (2006). A tandem affinity tag for two-step purification under fully denaturing conditions: application in ubiquitin profiling and protein complex identification combined with in vivocross-linking. Mol Cell Proteomics 5(4), 737-48. |
