Christopher C.W. Hughes
Molecular Biology & Biochemistry
School of Biological Sciences
Phone: (949)824-8771
Email: cchughes@uci.edu
darwin.bio.uci.edu/~cchughes/
http://www.faculty.uci.edu/profile.cfm?faculty_id=2498
Christopher Hughes
Dr. Hughes works on the genes that regulate angiogenesis - the growth of new blood vessels. There is currently a tremendous amount of interest in regulating blood vessel growth into tumors, thereby stalling their growth.
Selected Publications:
Sainson, R. C., Aoto, J., Nakatsu, M. N., Holderfield, M., Conn, E., Koller, E., and Hughes, C. C. (2005). Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis. Faseb J 19(8), 1027-9.
Ghajar, C. M., Blevins, K. S., Hughes, C. C., George, S. C., and Putnam, A. J. (2006). Mesenchymal stem cells enhance angiogenesis in mechanically viable prevascularized tissues via early matrix metalloproteinase upregulation. Tissue Eng 12(10), 2875-88.
Holderfield, M. T., Henderson Anderson, A. M., Kokubo, H., Chin, M. T., Johnson, R. L., and Hughes, C. C. (2006). HESR1/CHF2 suppresses VEGFR2 transcription independent of binding to E-boxes. Biochem Biophys Res Commun 346(3), 637-48.
Sainson, R. C., Johnston, D. A., Chu, H. C., Holderfield, M. T., Nakatsu, M. N., Crampton, S. P., Davis, J., Conn, E., and Hughes, C. C. (2008). TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype. Blood 111(10), 4997-5007.
Holderfield, M. T., and Hughes, C. C. (2008). Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis. Circ Res 102(6), 637-52.
Hughes, C. C. (2008). Endothelial-stromal interactions in angiogenesis. Curr Opin Hematol 15(3), 204-9. |
