Anand Ganesan
Dermatology, School of Medicine
Phone: (949) 824-2926
Email: aganesan@uci.edu
http://www.hs.uci.edu/dermatology/Ganesan%20Research.pdf
http://www.hs.uci.edu/dermatology/Faculty.aspx?id=70
Anand Ganesan
Dr. Ganesan’s lab utilizes systems level approaches to identify the genes that regulate melanin production and chemoresistance in melanoma cells. They utilize cell biological and biochemical approaches to characterize these molecules, and utilize skin equivalent models to examine the function of these genes in human skin. Through these studies, they seek to identify new molecular markers for melanoma development and targets for rational drug design.
Selected Publications:
Hall, J. A., Ganesan, A. K., Chen, J., and Nikaido, H. (1997). Two modes of ligand binding in maltose-binding protein of Escherichia coli. Functional significance in active transport. J Biol Chem 272(28), 17615-22.
Ganesan, A. K., Frank, D. W., Misra, R. P., Schmidt, G., and Barbieri, J. T. (1998). Pseudomonas aeruginosa exoenzyme S ADP-ribosylates Ras at multiple sites. J Biol Chem 273(13), 7332-7.
Ganesan, A. K., Mende-Mueller, L., Selzer, J., and Barbieri, J. T. (1999). Pseudomonas aeruginosa exoenzyme S, a double ADP-ribosyltransferase, resembles vertebrate mono-ADP-ribosyltransferases. J Biol Chem 274(14), 9503-8.
Ganesan, A. K., Vincent, T. S., Olson, J. C., and Barbieri, J. T. (1999). Pseudomonas aeruginosa exoenzyme S disrupts Ras-mediated signal transduction by inhibiting guanine nucleotide exchange factor-catalyzed nucleotide exchange. J Biol Chem 274(31), 21823-9.
Ganesan, A. K., Kho, Y., Kim, S. C., Chen, Y., Zhao, Y., and White, M. A. (2007). Broad spectrum identification of SUMO substrates in melanoma cells. Proteomics 7(13), 2216-21. |
